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Fig 4

ID: ZDB-IMAGE-210503-149
Publication: Wright et al., 2021 - Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis
All Figures: Figures for Wright et al., 2021

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Figure Caption

Fig 4 Increased miR-206 knockdown-associated neutrophils prevent bacterial dissemination.

(A-B) Representative images of bacterial granulomas in trunk-infected control and miR-206 knockdown embryos. (C) Quantification of M. marinum burden in trunk-infected control and miR-206 knockdown embryos. (D-E) Representative images of M. marinum-neutrophil interactions in trunk-infected control and miR-206 knockdown embryos. Neutrophils are red Tg(lyzC:dsred) and M. marinum is green (wasabi); co-localisation is indicated by yellow fluorescence. (F) Quantification of the proportion of the bacterial fluorescence overlapping with neutrophil fluorescence (co-localisation yellow fluorescence in D-E) in trunk-infected control and miR-206 knockdown embryos. Each data point represents the mean of 6 foci of infection from 6 separate embryos with SEM shown. Differences between groups was calculated using multiple t-tests and the Holm-Sidak method.

Acknowledgments

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