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Figure 9 The inducing melanogenesis activity and combinational design of components, and response surface methodology and contour plots of melanogenesis effect for component combinations. (A) Zebrafish melanin phenotype in each combination group. (B) The relative of melanin contents (% of control), results shown are mean ± SEM. Data were analyzed by ANOVA followed by post hoc Tukey test. n = 30 zebrafish, ### p < 0.001 vs. control, ns, non-significant, *** p < 0.001, ** p < 0.01, * p < 0.05 vs. PTU-2. (C) 3D response surface of the relative of melanin contents (% of control). (D) The results of this figure were predicted by the data reported in Table 1.