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FIGURE 5 mRNA-miR interactions across FRCs based on experimentally validated predictions. (A) FRC-mRNA-miR co-regulatory network based on TFmiR gene-miR interactions. Only mRNA-miR pairs with reverse expression directions were considered for the network. (Red) FRCs, (Blue) miRs, (Yellow) miRs that were differentially expressed across 4 or more FRCs, with larger nodes denoting higher number of FRCs. mRNAs are represented within the connected lines. (B) Selected miRs that were decreased across multiple FRCs, with fold changes and major functions (based on GO analysis) of their anti-correlated mRNA targets in specific FRCs. Numbers represent FRC classes based on Figure 1. TBPH and TCPP not represented since there were no miR disruptions.