|
Figure 12 The effects of protamine sulfate (PS) alone and together with N(ω)–nitro–l–arginine methyl ester (l–NAME) on mean blood pressure (MBP). The course of MBP was tracked for 60 min after short–duration intravenous infusion (5 min; 2 mL/h) of PS (15 mg/kg) following intravenous administration of vehicle (VEH; 1 mL/kg) or l–NAME (25 mg/kg; 1 mL/kg). Results are shown as means (line) with SEMs (a) and as medians with ranges (b). The MBP values at 0 min of the experiment were 121.4 (86.6–138.0) for VEH, 139.3 (130.4–153.3) for PS 15 mg/kg, 124.9 (107.1–119.8) for PS 10 mg/kg + l–NAME, and 132.5 (118.5–138.9) for l–NAME alone. Note: * p < 0.05, ** p < 0.01 vs. VEH, ^ p < 0.05 vs. PS 15 mg/kg, Kruskal–Wallis ANOVA with Dunn’s post–hoc test, n = 3–5.