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Fig. S5
Figure S5. CRISPR-generated hox11 loss-of-function mutants, related to Figure 6 Mutant lines of hox11 paralogs. (A) hoxa11a (B) hoxa11b (C) hoxd11a generated by CRISPR-Cas9 targeted gene editing. Shown is the targeted wild-type sequence as well as the sequence for the generated mutant alleles (blue box indicates guide target sequence). (D) Representative singular and compound mutants. All mutant combinations are viable and fertile. Scale bars 500 μm.
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Reprinted from Cell, 184(4), Hawkins, M.B., Henke, K., Harris, M.P., Latent developmental potential to form limb-like skeletal structures in zebrafish, 899-911.e13, Copyright (2021) with permission from Elsevier. Full text @ Cell