ZFIN Image: Ross et al., 2021, FIGURE 2

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Figure Caption

FIGURE 2

mCH is present at long genes with low expression levels. (A) mCH/CH levels, mCAC/CAC levels, and gene expression represented as transcripts per million (TPM) in adult zebrafish brains. (B) Genome browser snapshot of mCAC/CAC levels in cluster 1 (red) and cluster 2 (black) genes in adult brains. (C) Comparisons of gene length (top left), average gene mCAC/CAC (top right), average exon mCAC/CAC (bottom left) and average intron mCAC/CAC (bottom right) in genes with high (cluster 1) and moderate/low levels of mCAC/CAC (cluster 2) (Wilcoxon test, ∗∗∗P < 0.001). (D) Tc1-like element percentage of total gene length in genes with high (cluster 1) and moderate/low levels of mCAC/CAC (cluster 2) (Wilcoxon test, ∗∗∗P < 0.001). (E) Average expression levels (TPM) in 6-month old brains (n = 5) and neurons (n = 30) at genes with high (cluster 1), or moderate/low (cluster 2) mCH, and a random subset of genes (n = 1,860) sampled from cluster 2 (Wilcoxon test, ∗∗∗P < 0.001).

Acknowledgments

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