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Fig. 3
TPP indicates differential effects of napabucasin treatment on selected proteins. Stat33 (A) does not show any shift, whereas Stat5 (B) shows a small shift. However, a shift was detected in Aldh1a2 (C) and Aldh1a3 (D). The known interactor of napabucasin Nqo1 (E) shows no shift. Interestingly, another known interactor, Pora, (F) shows a shift indicating destabilization. Data points (n = 2 independent experiments) are shown as mean ± SEM, melting curve fitting was performed according to chemical denaturation theory.
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