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Figure 6 Phylogenetic history of the main components of paracellular and transcellular migration. Dark blue represents homologs found in respective genes. Light blue represents orthologs found for a gene family. Light red represents non existing orthologs or homologs. Almost all exclusive transcellular route genes identified are ancient except for CAVLIN1 and PLVAP, which both first appear in Danio rerio. Most genes that are exclusively active in the paracellular route have recently diverged such as CX43, JAMs, JAML, Occludin, PECAM1, VE-cadherin. Genes that are active in both routes are mostly ancient such as RhoA, RhoG, SRC, SRF VASP, CDC42, CTNNB1 and VWF.