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Figure 1 Workflow used in this report. (a) AI text mining procedure was done in various phases. First, answers for the imposed question were collected. Secondly, answers were filtered and gene names were extracted. Thirdly, the resulting genes were clustered according to their reported function into a paracellular pathway component, transcellular component, or both. Fourthly, phylogenetic analysis was done and lastly, functional conservation for critical genes was performed. (b) The genes resulting from the AI step were categorized based on literature review into one of three groups; shared genes (in navy blue) and paracellular (P) and transcellular (T) (in light red).