ZFIN Image: Etzrodt et al., 2021, Fig. 3

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Fig. 3

Functional consequences of MIR155 overexpression and inhibition in mice. B6.Cg-Mir155tm1.1Rsky/J knockout mice and wildtype litters were challenged with LPS (17.5 mg/kg BW i.p.) or vehicle (0.9% NaCl) and killed after 16 h. a Bar graphs showing Evans blue extravasation in the lung of healthy control mice (CTR, n = 5) and LPS challenged B6.Cg-Mir155tm1.1Rsky/J knockout mice (n = 3–12) b–d Perivascular fluid cuffs (lung cuffing) were evaluated. b PAS staining indicating the bronchi (b), its corresponding arterial vasa vasorum (a) and cuffing (black arrows). c Bar graph showing the percentage of lung cuffing. Indicating a significant difference between the LPS challenged MIR155^+/+ (n = 8) and MIR155^+/− group (n = 9; p = 0.001). d Bar graph showing the lung cuffing severity score of single bronchi (n = 41–263 arteriolae per group) from a total of 27 mice. (*p < 0.05, **p < 0.01, ***p < 0.0001)

Acknowledgments

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