ZFIN Image: Trivellin et al., 2020, Fig. 6

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Figure Caption

Fig. 6 Fig. 6. MZgpr101 mutants are temperature-sensitive. a) Lower incubation temperatures (22 and 24.5 °C) adversely affect MZgpr101 embryonic development. Each column indicates the percentage of phenotypes observed at morphological inspection at 1 dpf. The total number of analyzed embryos is shown at the top of each column. b) MZgpr101 (n = 48) and WT (n = 17) fertilized embryos were reared at 24.5 °C and analyzed by time-lapse microscopy from 1-cell stage to 24 hpf. All WT embryos developed normally. The graph shows the percentage of MZgpr101 embryos that died at either the blastula or gastrula stages, and the phenotypes and percentage of the surviving embryos.

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Reprinted from Molecular and Cellular Endocrinology, 520, Trivellin, G., Tirosh, A., Hernández-Ramírez, L.C., Gupta, T., Tsai-Morris, C.H., Faucz, F.R., Burgess, H.A., Feldman, B., Stratakis, C.A., The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish, 111091, Copyright (2020) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.