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Figure 5

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Publication: Zhang et al., 2021 - SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa
All Figures: Figures for Zhang et al., 2021

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Figure 5

Detrimental effects of SNRNP200 p.Arg2030Cys in zebrafish. (A) Morphological changes at 3 dpf after injections of SNRNP200^WT, SNRNP200 p.Arg2030Cys. There is a significant difference of systemic deformations among groups. (B) Statistics of normal, deformed, and dead zebrafish after injection with SNRNP200 p.Arg2030Cys, SNRNP200^WT from 2 to 4 dpf. Data are shown as mean + SD from technical triplicates. n: total number of larvae for each group from triple experiment. ***P < 0.001. (C) Immunostaining analysis of the zebrafish larvae injected with different mRNAs at 3 dpf for rhodopsin (green). The normal zebrafish revealed abundant expression of rhodopsin in the IS/OS layer (D–I) by contrast, the reactivity of rhodopsin was significantly diminished in SNRNP200^c.C6088T-injected larvae.

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