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Fig. 1 The CreLite system. The light‐inducible protein binding pair, truncated phytochrome B (PhyBΔ) and the active protein binding domain of phytochrome B interacting factor 6 (PIF6APB) are fused with C‐terminus Cre (CreC) and N‐terminus Cre (CreN), respectively. A cofactor analog, phycocyanobilin (PCB), is required for PhyBΔ to be functional. Once exposed to red light (λmax = 650 nm), the PhyBΔ and PIF6APB bind each other and bring the two halves of Cre together, resuming its recombinase activity
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