Fig 5

Fig 5

(A) Tracking of the growth of wildtype, hmx1^mut10 and hmx1^mut150 eye from 1 dpf to 3 dpf. Hmx1^mut10 and hmx1^mut150 eyes are reduced in size compared to wildtype embryos at 2 and 3 dpf stages. (B) Lens growth expressed as ratio lens/whole eye. hmx1^mut10 and hmx1^mut150 lenses are smaller at 3 dpf. (C) Wildtype, hmx1^mut10 and hmx1^mut150 eyes at 5 dpf. Wildtype and hmx1^mut10 present a fully developed lens (5C, a-b), while hmx1^mut150 embryos exhibit two opposing phenotypes (5C, c); on the left side a recovered lens is presented, while on the right a smaller lens presenting a clear phenotype called microphakia. (5C, d) graphic representation of lens/eye ratio; hmx1^mut150 presents a wide range of distribution of the lens size. Red arrows indicate the lens at 5 dpf. Data are expressed as mean of three to 5 experiments. *; P<0.05 (ANOVA test). Bar, C 100 μm.