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ZDB-IMAGE-210130-4

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Source: Figures for El Fersioui et al., 2021

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Figure Caption

Schematic representation of the HMX1 predicted promoter region in zebrafish, human and mouse genomes (A). Note the presence of complete Hmx1 binding sites (CAAGTG) and the minimal binding core (CAAG). Activity of HMX1 on human UHRF1 promoter (B). The pGL3-Uhrf1 reporter plasmid was cotransfected with pcDNA3.1 empty, pcDNA3.1-Hmx1 expression vector, and pcDNA3.1-Hmx1 del SD1, del SD2, or del HD. HMX1 inhibits UHRF1 transcriptional activity by 40%. HMX1 del SD1, HMX1 del SD2 and HMX1 del HD had no statistical significant effect. Luciferase activity was normalized against β-galactosidase activity. Data are expressed as mean of three or more experiments. *; P<0.05 (ANOVA test).

Acknowledgments

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