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Figure 5

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Publication: Brunal et al., 2021 - Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity
All Figures: Figures for Brunal et al., 2021

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Figure 5

Whole-brain activity map showing significant regional differences following Cx36 blocking drug mefloquine and PTZ exposure in wild-type zebrafish larvae. Dorsal and lateral view of zebrafish larvae brain. (A–D) Images show regions with significantly increased (green) or decreased (magenta) activity compared to DMSO and embryo medium (vehicle) treated fish (n = 9). (A) 2 mM PTZ (n = 10). (B) 5 mM PTZ (n = 10) (C) 10 mM PTZ (n = 10). (D) 20 mM PTZ (n = 10). (E–H) Images show regions with significantly increased (green) or decreased (magenta) activity compared to mefloquine and embryo medium (vehicle) treated fish (n = 9). (E) 2 mM PTZ (n = 10). (F) 5 mM PTZ (n = 8). (G) 10 mM PTZ (n = 10). (H) 20 mM PTZ (n = 10). (I–M) Images show regions with significantly increased (green) or decreased (magenta) activity in mefloquine treated fish, compared to DMSO (vehicle) treated fish. (I) embryo medium (0 mM PTZ) (n = 9). (J) 2mM PTZ (n = 10). (K) 5 mM PTZ (DMSO n = 10, mefloquine n = 8) (L) 10 mM PTZ (n = 10). (M) 20 mM PTZ (n = 10). Mef: mefloquine.

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