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Publication: Petratou et al., 2021 - The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor
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Fig 1 A progressive fate restriction model for iridophore development from multipotent NCCs.

Schematic representation of the previously described model of iridophore generation from the NC, along with the expression characteristics and potential fate choices of individual arising cell types [14]. Genes actively expressed in each cell are indicated with a “+” sign. tfec is initially co-expressed with eNCC specification factors, which gradually become downregulated (red font, vertical red arrow), while lineage-specific factors become upregulated (green font). Proteins indicated on the vertical black arrows are considered important for the respective fate specification step. MiT, microphthalmia family transcription factors; PNS, peripheral nervous system.

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