ZFIN Image: Li et al., 2020, FIGURE 7

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FIGURE 7

Naringin attenuates the activation of the apoptotic‐ and pyroptosis‐related pathway in vitro and in vivo. (A and C) Real‐time PCR analysis of the mRNA levels of apoptotic (P53, Bax, Caspase‐3) and pyroptosis (caspb, caspa) related genes in zebrafish larvae treated with the presence/absence of Nar (400 µmol/L) and the corresponding ototoxin (CP 200 µmol/L, GM 100 µmol/L, Neo 100 µmol/L). Data are expressed as the mean ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05. Black asterisks compared versus corresponding control. (B and D) Real‐time PCR analysis of the mRNA levels of apoptotic‐ (Bcl‐2, Bax, Caspase‐3) and pyroptosis‐ (Caspase‐1, NLRP3) related genes in HEI‐OC1 cells treated with the presence/absence of Nar (100 µmol/L) and the corresponding ototoxin (CP 10 µg/mL, GM 50 µmol/L, Neo 50 µmol/L). Data are expressed as mean ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05. Black asterisks compared versus corresponding control

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