ZFIN Image: Gene Ontology Consortium, Figure 1.

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Figure 1.

Gene Ontology Causal Activity Model (GO-CAM) of ‘C. elegans defense response to Gram negative bacterium in the intestine’. A GO-CAM is centered around at least one molecular activity that takes place within a specific biological context. This part of the GO-CAM details the flow of causal influences between molecular activities with the vocabulary from the Relation Ontology. For instance, the ‘MAP kinase tyrosine/serine/threonine phosphatase activity’ negatively regulates the MAP kinase activity of pmk-1 Cele that occurs in cytosol, which has the downstream effect of negatively regulating the ‘DNA binding transcription factor activity, RNA polymerase II-specific’ of atf-7 cele that occurs in nucleus.

Acknowledgments

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