ZFIN Image: Langenbacher et al., 2020, FIGURE 3

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Figure Caption

FIGURE 3

Transmission electron microscopy analysis of MCU mutant ventricles. Representative TEM images of WT (A–C) and MCU(D–F) ventricular cardiomyocytes. (A,D) WT sarcomeres display clear Z-lines (arrows in A) separated by parallel bands of myosin thick filaments. MCU Z-lines are less well defined and patchy (arrows in D) and thick filaments are sometimes disorganized. (B,C) WT myofibrils are closely associated with oval-shaped mitochondria containing tightly packed cristae (arrowheads in B mark examples, C shows more examples). (E,F)MCU myofibrils are also closely associated with mitochondria, but they are less electron-dense and display a round and swollen morphology with more loosely packed cristae [arrowheads in (E) mark examples, (F) shows more examples]. Scale bars indicate 500 nm.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Physiol.