ZFIN Image: Wague et al., 2020, Figure 1.

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Figure Caption

Figure 1. Functional validation of azi-isoflurane activity on TREK1 channels.

Representative two electrode voltage clamp recordings demonstrate the potentiating effects of saturating doses of isolflurane (A) and azi-isoflurane (B). Chemical structures of isoflurane and azi-isoflurane are shown. (C) Fold effect of administration of saturating doses of either isoflurane or azi-isoflurane on TREK1 outward current, as determined by the ratio of the recorded current at a voltage of 0 mV, immediately prior to and following administration of volatile anesthetic (VA) agent. No significant difference was found between the responses of TREK1 to isoflurane versus azi-isoflurane, unpaired two tailed t-test p value of 0.11 (D) Dose response curve for azi-isoflurane activation of TREK1. Data derived from n > 6, N > 2 experimental observations. Error bars in panels C and D are mean ± SEM.

Acknowledgments

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