ZFIN Image: Domenichini et al., 2020, Fig. 3

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Figure Caption

Fig. 3

Effect of JVG045 on primary pancreatic cancer cells from the KPC mouse model.a Representative images showing the effect of JVG045 at 10 μM on the number of primary pancreatic cancer cells isolated from the KrasLSL.G12D/+; p53R172H/+; PdxCretg/+ (or KPC) mouse model, compared to DMSO. b Graph showing a dose response effect of JVG045 on KPC cells, with 5 and 10 μM being the most effective concentrations. c Representative mages showing the effect of JVG045 (10 μM) on anchorage-independent colony formation of KPC cells, compared to DMSO. d Graph showing a significant reduction in KPC colonies formed in the presence of JVG045 (10 μM), compared to DMSO. Experiments were performed in triplicate and showed as Mean ± SEM

Acknowledgments

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