ZFIN Image: Domenichini et al., 2020, Fig. 6

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Figure Caption

Fig. 6

Effect of JVG045 on zebrafish and mouse xenografts.a Brightfield images and images showing DiL-labelled HPAF-II tumour xenografts in 5 days post-fertilisation zebrafish embryos untreated (DMSO) or treated with JVG045 (10 μM) for 3 days after injection of HPAF-II human pancreatic cancer cells. Scale bar 100 μm. b Graph showing the effect of 10 μM JVG045 in reducing the tumour burden in zebrafish embryos (n = 12), compared to control embryos (DMSO, n = 6). c Representative images of HPAF-II tumours from mouse xenografts receiving control treatment (vehicle) or treated with JVG045 (30mh/kg) for 25 days. d Graph showing tumour growth of HPAF-II xenograft mouse models treated with vehicle (n = 8) and 30 mg/kg JVG045 (n = 9). e Graph showing the tumour weight at the end of the experiment of HPAF-II xenograft mouse models treated with vehicle (n = 8) and 30 mg/kg JVG045 (n = 9). Results are expressed as Mean ± SEM

Acknowledgments

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