ZFIN Image: Rodrigues da Silva et al., 2020, Figure 4

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Figure Caption

Figure 4

(A) Experimental strategy. (B) Bradycardia after 1 h of incubation of free articaine (ATC) and articaine-loaded nanostructured lipid carriers at concentrations of 0.5 and 1 mM and (C) their respective controls without articaine. (D) Touch reaction after 1 h incubation of ATC and articaine-loaded nanostructured lipid carriers at concentrations of 0.5 and 1 mM and (E) their respective controls without articaine. Touch reaction scale: Score 0 means larva did not react, score 1 means larva react between 1 and 3 s after touch, and score 2 means larva react in less than 1 s after touch. n = 24. E3 = medium only, no treatment (control). Statistical analysis: one-way ANOVA and Tukey post-hoc test. Statistical significance: ***p < 0.001, ****p < 0.0001; n.s. non-significant.

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