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Figure 7

ID: ZDB-IMAGE-201116-20
Publication: Whittle et al., 2020 - MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin
All Figures: Figures for Whittle et al., 2020

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Figure Caption

Figure 7 Para‐aminoblebbistatin ameliorates the <italic>smyhc1</italic><sup>R673H</sup> larval phenotype

Representative morphologies of smyhc1^+/+, smyhc1^R673H/+, and smyhc1^R673H/R673H larvae at 2 dpf after 24‐h treatment with 0.25% DMSO (control) or 25 μM para‐aminoblebbistatin. All larvae treated with para‐aminoblebbistatin develop a slight dorsal tail curve and pericardial edema regardless of genotype. All para‐aminoblebbistatin‐treated smyhc1^R673H/+ (n = 9) and smyhc1^R673H/R673H (n = 3) larvae are indistinguishable from smyhc1^+/+ unlike the untreated larvae which have markedly curved or distorted body axis.

Representative images of smyhc1^+/+, smyhc1^R673H/+, and smyhc1^R673H/R673H larvae at 3 dpf after 48‐h treatment with 0.25% DMSO (control) or 25 μM para‐aminoblebbistatin. All larvae treated with para‐aminoblebbistatin develop a slight dorsal tail curve and pericardial edema regardless of genotype. Para‐aminoblebbistatin‐treated smyhc1^R673H/+ (n = 9) and smyhc1^R673H/R673H (n = 3) larvae are indistinguishable from smyhc1^+/+ unlike the untreated larvae which have markedly curved or distorted body axis.

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.