IMAGE

Figure 4

ID: ZDB-IMAGE-201116-14
Publication: Whittle et al., 2020 - MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin
All Figures: Figures for Whittle et al., 2020

Image

Figure Caption

Figure 4 <italic>smyhc1</italic> mutants exhibit skeletal abnormalities in adulthood

Gross morphology of smyhc1 mutant adults. Most smyhc1^−/− adult fish display dorsal tail curvature, while smyhc1^R673H/+ adults have a shortened body axis and variable spinal curves.

Alizarin red staining of bone shows spinal curvature but no bony fusions in the skeleton of smyhc1^−/− adults, in contrast to the compression and fusion of vertebrae seen in smyhc1^R673H/+ adults. Distal tail regions are highlighted and enlarged.

Quantification of skeletal phenotype severity in adults. Representative examples of fish in each of the four phenotypic groups (normal, mild, moderate, and severe) are shown in Fig EV3. Scale bars represent a length of 5 mm.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.