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Figure Caption

Figure 2—figure supplement 4. Multiple sequence alignment of OG_8220, another bilaterian-specific orthogroup without known domains.

View of a 234 AA alignment with 135 sequences from 22 deuterostomes, 8 ecdysozoans, and 9 lophotrochozoans, illustrating the existence of domain-like conservation patterns despite the absence of known protein domains. Short stretches of unaligned sequences were removed for clarity. Colouring of amino acids reflects chemical similarity (UGENE standard colour scheme; Okonechnikov et al., 2012). Bar chart on top displays sequence conservation of alignment columns beneath. Sequences are ordered according to their origin.

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