Figure 2—figure supplement 1.

Figure 2—figure supplement 1.

(A) Reference proteomes of 28 representative metazoans (downloaded from uniprot.org) were scanned for the presence of C₂H₂ zinc finger proteins. For each species, the number of proteins with ≥6 domains is plotted. (B) Boxplot representation of the number of poly-ZF proteins per genome in non-bilaterian Metazoa (four species) vs. Bilateria (24 species) using scanning results of panel A. (C) Evolutionary origin of poly-ZF proteins. On the basis of our orthology database (BigWenDB), we inferred lineage-specific orthogroups for four lineages, opisthokonts (O), metazoans (M), eumetazoans (Eu), and bilaterians (B), and analysed those orthogroups for the presence of C₂H₂ poly-ZF proteins with ≥6 domains. The number of such proteins vs. the total number of lineage-specific orthogroups is displayed in red under each node. "O" indicates origin in the ancestor of opisthokonts or earlier.