Figure 7—figure supplement 1.

Figure 7—figure supplement 1.

Maximum likelihood phylogenetic analysis of 53 metazoan NTRK and ROR1 sequences (outgroup), aligned over 602 AA. Proportion of gaps and completely undetermined characters in the corresponding alignment: 16.84%. Sequences were collected from different sources: NTRK receptor sequences from protostomes are derived from OG_8965–1.4 of the 1.4 clustering, an orthogroup containing RTKs only (Supplementary file 1–Supplementary Table 24). Deuterostomian NTRK sequences were collected at www.uniprot.org. Non-bilaterian ROR1 sequences were obtained from OG_6493–1.4, the ROR1-specific orthogroup of the 1.4 clustering (Supplementary file 1–Supplementary Table 24), while most bilaterian ROR1 sequences were downloaded from www.uniprot.org. Branch labels correspond to the results of SH-aLRT (Shimodaira–Hasegawa-like approximate likelihood ratio test, left) and UFBoot (ultrafast bootstrap approximation, right) as implemented in IQ-TREE (Nguyen et al., 2015).