Figure 2

Figure 2

Hill plots of the inhaled and IV anesthetics. Zebrafish respond to inhaled anesthetics, halothane (A), isoflurane (B) and sevoflurane (C), and IV anesthetics, propofol (D) and etomidate (E), at physiological concentrations. For all anesthetics, the SPONT (blue) is lost at a lower concentration as compared to the TAP (green). For the IV anesthetics, ELEC (purple) is also lower than SPONT. Interestingly, although propofol TAP (green) and ELEC (purple), are similar, etomidate requires a sevenfold higher dose of drug for TAP versus ELEC. All graphs were created with 3–8 replicates per point and 15–18 zebrafish larvae used per replicate.