ZFIN Image: Kumar et al., 2020, Fig. 3

Image

Figure Caption

Fig. 3 Global conformational changes and altered inter-domain interactions during GlyR gating.

a A side-view of the ECD interface in GlyR–Apo and GlyR–Gly. The principal subunits are colored (GlyR–Apo: salmon red and GlyR–Gly: slate blue) while the complementary subunits are shown in shades of gray. b A side view of the TMD in GlyR–Apo and GlyR–Gly conformations. c Interactions at the subunit- and domain-interfaces between ECD–ECD, ECD–TMD, and TMD–TMD in GlyR–Apo (left) and GlyR–Gly (right). The residues involved in the interactions are shown in sticks and interactions are highlighted by black dashes. Mutations at positions shown in green are associated with hyperekplexia².

Acknowledgments

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