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Fig. 3.

ID: ZDB-IMAGE-200910-20
Publication: Oppel et al., 2020 - suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma
All Figures: Figures for Oppel et al., 2020

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Figure Caption

Fig. 3.

Observation of multiple tumor foci in p53/nf1/suz12-deficient zebrafish lines. (A) Fluorescence microscopy image of an adult p53^+/−, nf1b^−/−, nf1a^+/⁻, suz12a^+/⁻, suz12b^+/⁻ fish bearing two independent GFP-positive tumors in abdominal and anal locations. (B) Proportion of fish with multiple lesions in different suz12-mutant populations with additional p53^+/−, nf1b^−/−, nf1a^+/⁻ or p53^+/−, nf1b^−/−, nf1a^+/+ backgrounds. Data are mean±s.d. of populations with any combination of three out of four (suz12^{+/−/−/−}), two out of four (suz12^+/+/−/−), or one out of four (suz12^+/+/+/−) suz12 alleles knocked out. The total number of fish analyzed is indicated (n). P-values were calculated using Student's t-tests. (C) Representative HE-stained sections of p53/nf1/suz12-deficient fish with two separate tumor foci. Squares indicate areas shown in magnified images below.

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