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Publication: Spinazzola et al., 2020 - Effect of serotonin modulation on dystrophin-deficient zebrafish
All Figures: Figures for Spinazzola et al., 2020

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Fig. 1.

Experimental design of the short-term zebrafish birefringence assay. (A) Heterozygous sapje or sapje-like pairs were mated and their respective embryos were collected and pooled. Drug treatment was initiated on 1 dpf and continued through 4 dpf when birefringence was analyzed. (B) Representative images of the patchy muscle birefringence pattern characteristic of sapje and sapje-like homozygous mutants compared to the highly organized sarcomere structure of (+/+) and (+/−) siblings. Given that the sapje and sapje-like dystrophin mutations are recessive, 25% of untreated offspring are expected to exhibit the affected muscle phenotype.

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