ZFIN Image: Creusot et al., 2020, Figure 2

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Figure Caption

Figure 2

Dabrafenib is a potent activator of hPXR on different human cancer cell lines. Results of luciferase assays showing dose–response curves for SR12813 and dabrafenib in (A) HG5LN GAL4-hPXR, (B) LS174T-hPXR, (C) HepG2-hPXR and (D) 22RV1-hPXR reporter cell lines. Results are expressed as a percentage of the maximal response obtained in the presence of 3 μM SR12813. Data are the mean ± sd of three to five independent experiments, **** p < 0.0001, *** p < 0.001, ** p < 0.01, * p < 0.1 (Student’s t-test) compared with DMSO-treated cells.3.2. Time-Resolved Fluorescence Energy Transfer Experiments.

Acknowledgments

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