ZFIN Image: Creusot et al., 2020, Figure 1

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Figure Caption

Figure 1

Effects of dabrafenib on the activation of human, mouse and zebrafish pregnane X receptor (PXR) and human constitutive androstane receptor (CAR) nuclear receptors as measured by luciferase reporter assay. Activation has been measured in (A) HG5LN control cells or cells expressing GAL4 fusion with (B) human (hPXR), (C) mouse (mPXR) or (D) zebrafish (zfPXR) PXR, (E) human wild-type (hCAR) or (F) mutated (hCAR APYLT) hCAR LBD treated by DMSO (0.1%), SR12813 3 μM, PCN 3 μM, clotrimazol 1 μM, CITCO 1 μM and dabrafenib 3 μM. Results are expressed as fold induction as compared to control. Data are expressed as the mean ± sd of three independent experiments, **** p < 0.0001, *** p < 0.001, ** p < 0.01 (Student’s t-test) compared with DMSO-treated cells.

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