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Fig. 1 Short telomeres promote tumorigenesis in a noncell autonomous manner. (A) Experimental setup for the generation of zebrafish chimeras. Donor cells are transplanted from a Tg(mitfa:HRASG12V; β-actin:GFP) embryo at the blastula stage into embryos resulting from an in cross of tert+/−; casper zebrafish. (B) Representative images of adult chimera zebrafish harboring melanoma in either WT or tert−/− recipients. (C) Melanoma occurrence over time in chimeric fish. tert−/− recipient fish have a higher risk of tumorigenesis than WT and het recipient fish. *P < 0.05.
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Full text @ Proc. Natl. Acad. Sci. USA