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Fig. 2
Hydroxychloroquine causes dose-dependent effects on hair cells in the zebrafish lateral line, similar to chloroquine. Dose-response functions show that hair cells exposed to hydroxychloroquine (solid line) survive at a similar rate as those exposed to chloroquine (dashed line) after a 24-h treatment period. Two-way ANOVA demonstrate a small, but significant effect, with hydroxychloroquine being slightly more toxic (F = 4.774, p = 0.03). Error bars represent ±1 standard deviation.
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Reprinted from Hearing Research, 395, Davis, S.N., Wu, P., Camci, E.D., Simon, J.A., Rubel, E.W., Raible, D.W., Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity, 108019, Copyright (2020) with permission from Elsevier. Full text @ Hear. Res.