IMAGE

Fig 2

ID

ZDB-IMAGE-200718-31

Genes

Tomato
YFP

Publication

Deveau et al., 2020 - Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

All Figures

Figures for Deveau et al., 2020

Image

Figure Caption

Fig 2 Live confocal imaging of larval eyes at 4- and 5-days post fertilization (dpf).

(A) A confocal cross section of a wild type (6BP+/+) (N = 4) larval eye shows a ring of cone layer tdTomato fluorescence under control of a trβ2 promoter in the red cones at the outer edge of the retina. (B) A 6BP+1+/- heterozygote maintains (N = 7) trβ2 fluorescence, but the 6BP+1-/- mutant (N = 14) (C) has no trβ2 fluorescence. The 3BP wild type (N = 12) (D), heterozygote (N = 23) (E), and mutant (N = 5) (F) all exhibit trβ2 fluorescence shown through mYFP expressed by a trβ2 promoter. Eyes are imaged from the larval anterior side showing a cross-section ring of cones. Fluorescence in a ring or semi-ring formation indicates the presence of trβ2 activity. Missing sections of the rings are due to image planes cutting through the cornea.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.