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Publication: Angileri et al., 2020 - dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye
All Figures: Figures for Angileri et al., 2020

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Figure 1

Disruption of dnmt1 function results in CMZ defects. A–F DAPI staining of nuclei (gray) within the CMZ (white dotted lines delineate CMZ boundaries) of siblings (A–C) and dnmt1^−/− (D–F) larvae from 3 to 5dpf. G Average number of all nuclei within the central retina of siblings and mutants. Each data point is the average of cell counts from three different 12 μm sections in one eye of a single larva. H Proportional changes of dnmt1^−/− retinal domains (GCL, INL, ONL, and CMZ) relative to siblings (set to 100%). Colors correspond with retinal domains in diagram. Scale bars = 30 μm. **p < 0.005, ***p < 0.0005; ****p < 0.00005. Dorsal is up in all images.

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