ZFIN Image: Ibrahim et al., 2020, Fig. 6.

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Figure Caption

Fig. 6.

Hyperglycemia is induced without overt β cell death and ROS-mediated stress is seen in surrounding cells of the islet. (A) After treatment with 0.5, 1 and 2.5 µg/ml doxycycline, there was no subsequent increase in Casp3* expression in these embryos. (B) A hyperglycemic phenotype was observed in embryos treated with 1 µg/ml and 2.5 µg/ml doxycycline. n=3. *P<0.05 (individual t-tests). (C) The expression of CellRox Deep Red is enriched in β cells and is also observed in surrounding cells of the islet (outlined by dashed lines).

Acknowledgments

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