ZFIN Image: Blanco-Sánchez et al., 2020, Fig 2

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Figure Caption

Fig 2 YPEL3 is an evolutionarily conserved disease-causing candidate gene.

(A-C) ypel3 is maternally deposited and expressed during neural development in zebrafish. (A) Two-cell stage embryo. (B-C) Transverse sections. (B) At 24 hours postfertilization (hpf), ypel3 is expressed broadly in the spinal cord and sparsely in the somites (red arrows). (C) At 56 hpf, ypel3 is expressed in the spinal cord and in the region where the motor roots develop (red arrows). (D) Diagram of spinal cord domains, their derivatives, and molecular markers. The pMN domain (olig 2+) gives rise first to motoneurons, and then later oligodendrocytes (Briscoe et al., 2000; Jessell, 2000; Danesin and Soula, 2017). The p3 domain (nkx2.2+) is localized ventral to the pMN domain and gives rise to oligodendrocytes and a subset of perineurial cells (Clark et al., 2014; Kucenas et al., 2008b). Schwann cells (SC) are neural crest derivatives. Scale bar: 250 μm in A, 25 μm in B and C.

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Acknowledgments

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