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ID: ZDB-IMAGE-200627-25
Publication: Campinho et al., 2020 - Blood Flow Forces in Shaping the Vascular System: A Focus on Endothelial Cell Behavior
All Figures: Figures for Campinho et al., 2020

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Figure Caption

FIGURE 3

Hematopoietic stem cell emergence is blood flow dependent. (A) During definitive hematopoiesis, hematopoietic stem cell progenitors arise at the ventral side of the dorsal aorta (DA) via cell extrusion from the endothelium. (B) Potential hemogenic cells (blue) located at the ventral region of the DA are elongated along the anterior-posterior (AP) axis. (C) Cells are extruded from the endothelium by contraction of actomyosin that accumulated at the AP poles of the cell. (D) Concomitantly, the majority of endothelial cells move toward the ventral side of the DA (yellow arrows). At each heartbeat, the DA wall deforms asymmetrically: the deformation is highest (magenta) in the ventral region and lowest (blue) in the dorsal side. Drawings in (B,C) after Lancino et al. (2018).

Acknowledgments

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