ZFIN Image: Chestnut et al., 2020, Fig. 9

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Figure Caption

Fig. 9 A proposed model for the differentiation of vascular endothelial cells from the multipotent mesodermal progenitors in the LPM.

Wnt and FGF signaling promotes myocyte differentiation of multipotent progenitors in the lateral plate mesoderm (LPM). BMP signaling through its downstream effectors id1 and id3 promotes vascular endothelial differentiation. Additional LPM markers that include prrx1a, foxd1, foxd2 and others may be involved in this process, although their role is purely speculative at this point. Etv2 promotes vascular endothelial differentiation while directly or indirectly repressing myogenesis.

Acknowledgments

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