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Publication: Mazzola et al., 2020 - Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects
All Figures: Figures for Mazzola et al., 2020

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FIGURE 1

Positive correlation between NIPBL and RUNX1 expression in megakaryocytes derived from healthy donors and in bone marrow cells derived from 34 adult AML patients. A and B, Spearman's correlation between RUNX1 and RAD21 (A) or NIPBL (B) in cord blood megakaryocytes (MK) derived from healthy donors. C and D, Spearman's correlation between RUNX1 and RAD21 (C) or NIPBL (D) in bone marrow cells (BM) derived from 34 adult AML patients without aberrant RUNX1 alterations (mutations or translocations). E and F, Spearman's correlation between RUNX1 and NIPBL in 34 adult AML patients without (NPM1wt) (E) or with NPM1 mutation (NPMc+) (F). Spearman's correlation analysis showed a significant positive correlation of the ratio of RUNX1 expression only versus NIPBL, not versus RAD21,. r = Spearman's correlation coefficient

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