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Figure S2
Recombinant ANXA11 Undergoes Liquid-Liquid Phase Separation
A. Purified ANXA11 protein formed biological condensates.
Full-length wild type ANXA11 formed spherical, fusing liquid droplets at ANXA11 concentrations at 10μM facilitated by 10% dextran. Inset shows a fusion event between two phase separated liquid droplets.
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Reprinted from Cell, 179, Liao, Y.C., Fernandopulle, M.S., Wang, G., Choi, H., Hao, L., Drerup, C.M., Patel, R., Qamar, S., Nixon-Abell, J., Shen, Y., Meadows, W., Vendruscolo, M., Knowles, T.P.J., Nelson, M., Czekalska, M.A., Musteikyte, G., Gachechiladze, M.A., Stephens, C.A., Pasolli, H.A., Forrest, L.R., St George-Hyslop, P., Lippincott-Schwartz, J., Ward, M.E., RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether, 147-164.e20, Copyright (2019) with permission from Elsevier. Full text @ Cell