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Figure 4-figure supplement 3

ID: ZDB-IMAGE-200511-31
Publication: Volpatti et al., 2020 - Identification of drug modifiers for RYR1 related myopathy using a multi-species discovery pipeline
All Figures: Figures for Volpatti et al., 2020

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Figure 4-figure supplement 3 Chemical-genetic interactions were tested using zebrafish larval movement speed as a readout.

Compared to the average speed of DMSO WT controls, chemical-genetic interactions were not observed for 18 hits from the C. elegans screen when tested in this assay (Figure 4—figure supplement 2–3F–W). Data are presented as mean ± SEM movement speed (mm/s) normalized to DMSO-treated WT siblings for n = 2 independent experiments for (A–E), (G), (H), (K), (L), and (R), where sample size n = 19 or 20 for each treatment group in a set and n = 1 experiment and sample size n = 9 or 10 for the remainder. Statistical analysis by two-way ANOVA followed by Tukey’s multiple comparisons post-test. *p<0.05, **p<0.01, ***p<0.001.

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