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Figure 2-figure supplement 5
- ID
- ZDB-IMAGE-200511-24
- Publication
- Volpatti et al., 2020 - Identification of drug modifiers for RYR1 related myopathy using a multi-species discovery pipeline
- All Figures
- Figures for Volpatti et al., 2020
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Figure Caption
Figure 2-figure supplement 5
Tanimoto scores were calculated for each pair of compounds as a measure of structural similarity and similar clusters were identified via hierarchical clustering of Tanimoto scores (legend indicates the Tanimoto score). As shown, chemicals with similar molecular fingerprints are associated with similar annotated functions/targets. Fisher’s exact test was used to determine enrichment based on the number of structurally similar members in each cluster that were either hits or not hits out of the total number of the compounds in the library.
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