IMAGE

Figure 6

ID: ZDB-IMAGE-200424-6
Source: Figures for Soh et al., 2020

Image

Figure Caption

Figure 6

Selective Mutual Antagonism of pSmad2 and pSmad5 Allows Cells to Respond to Different Ratios of Nodal and BMP Signaling

Schematic of a parsimonious model explaining the present findings. The antagonism of pSmad2 and pSmad5 to foxi1 and gsc induction, respectively, allows cells with both high pSmad2 and pSmad5 to express eve1 without expressing foxi1 or gsc. The activation and inhibition arrows are an abstraction, and the underlying mechanisms may be direct or indirect.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.