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Fig. 8

ID: ZDB-IMAGE-200406-197
Publication: Pei et al., 2020 - A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation
All Figures: Figures for Pei et al., 2020

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Fig. 8 ErbB pathway inhibitor AG1478 partially rescues the hair cell regeneration deficiency in <italic>gemin3</italic>, <italic>gemin5</italic>, and <italic>smn1</italic> mutants.

a Quantification of regenerated hair cells in the AG1478-treated smn1^hg104 mutant embryos at 2 days post hair cell ablation. b Quantification of regenerated hair cells in AG1478-treated gemin3^hg105 mutant embryos at 2 days post hair cell ablation. c Quantification of regenerated hair cells in lateral line neuromasts in AG1478-treated gemin5^hg81 mutant embryos at 2 days post hair cell ablation. The slight reduction in the hair cells of the gemin3^hg105 heterozygotes treated with 5 µM of AG1478 could be due to drug toxicity to this genetic background, since it was not observed in the smn1^hg104 and gemin5^hg81 embryos. Graphs show the mean ± s.e.m. Statistical difference are indicated as: ns, P > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001. Analysis for each condition was done with ~40 embryos generated from a single pair of heterozygous carrier parents, ablated hair cells at 5 dpf, and then treated with 0, 2.5, or 5 µM of AG1478 from 5 to 7 dpf.

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