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Figure 1
Human chemokine signaling networks are highly promiscuous. There are 25 receptors and 45 ligands in the human chemokine signaling network including seven members of the CXCR family (green), 1 XCR (cyan), 10 CCR (blue), and 1 CX3CR (violet). The CXCL chemokines are shown in shades of pink, XCL in cyan, CCL in shades of blue, and CX3CL in violet. The color intensity of the lines connecting receptors and ligands indicates the binding specificity. Darker colors indicate a higher binding affinity. There are six characterized AKCRs (orange) that antagonize the function of conventional chemokine receptors (connected with lines) by binding one or more of their ligands.